leukocyte antigen (hla) class ii allele frequencies in female patients with breast cancer: a case control study
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abstract
background: the study aimed to examine the association between human leukocyte antigen (hla) class ii allele frequencies and breast cancer in iranian women. methods: a total of 100 patients with pathologically proven breast cancer who referred to cancer institute were randomly selected and compared with a group of age matched healthy blood donors (n = 80). hla class ii alleles were determined by amplification of dna followed by hla-typing using sequence-specific primer (ssp) for each allele. results: the frequency of hla-dqa1*0301 ( p =0.001, or=3.4) and hla-drb1*1303 ( p =0.02, or=2.3) among breast cancer patients was significantly higher than those in control group. hla-dqa1*0505 ( p =0.003, or=0.4), hla-drb1*1301 ( p =0.002, or=0.12) and hla-dqa1*0101 ( p =0.01, or=0.21) alleles showed negative association with breast cancer. conclusion: the findings suggest that hla-dqa1*0301 allele is mainly associated with increased risk of breast cancer in iranian female patients. hla-dqa1*0505 and hla-drb1*1301 alleles are suggested as protective genetic factors against breast cancer. the findings confirm that specific alleles of hla class ii influence breast cancer risk.
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Journal title:
basic and clinical cancer researchجلد ۳، شماره ۱، صفحات ۳۶-۴۴
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